Francesco Acerbi was born on 10/02/1988 in Vizzolo Predabissi, Italy. Until the age of 22, Acerbi played only in the lower tiers of the Italian football, before being purchased by the Serie B club Reggina. In 2011, Acerbi signed with Chievo Verona. Acerbi managed to draw the attention of A.C. Milan, who signed him the next summer. Having appeared in 10 games for the Rossoneri, Acerbi returned to Chievo to complete the season. In 2013, he signed with Sassuolo, where he would become an undisputed starter. In 2018, having made 173 appearances for the neroverdi, Acerbi transferred to Lazio.