Vicente Guaita was born on 10/01/1987 in Torrent, Spain. He graduated from the Valencia youth system after arriving there from CD Monte-sión at the age of 13, being promoted to the first team for the 2008–09 season following the retirement of longtime incumbent Santiago Cañizares. In 2009–10, Guaita joined, on loan, Segunda División's Recreativo de Huelva, where he was awarded the competition's Ricardo Zamora Trophy. On 31 July 2014, Guaita was sold to Getafe with a buy-back option. On 2 February 2018, Crystal Palace manager Roy Hodgson confirmed Guaita had agreed to join on a free transfer.