Dyego Sousa was born on 14/09/1989 in São Luís, Brazil. Sousa began his career at his hometown team Moto Club de São Luís' youth setup before moving to Sociedade Esportiva Palmeiras in 2005. In July 2010, Sousa moved abroad for the first time, joining Leixões S.C. In June 2011, Sousa switched continents again, signing for G.D. Interclube in Angola. Sousa returned to Portugal's second tier in 2012 with C.D. Tondela. On 13 July 2014, Sousa signed with PrimeiraC.S. Marítimo. Sousa agreed on 31 January 2017 to transfer to S.C. Braga. In 2019, he joined Chinese team Shenzhen FC.